Sarcomatoid carcinoma of the kidney in a MEN1 patient: case report and genetic profile.

نویسندگان

  • Tiziana Cavalli
  • Francesco Giudici
  • Gabriella Nesi
  • Francesca Marini
  • Francesca Giusti
  • Loredana Cavalli
  • Maria Luisa Brandi
  • Francesco Tonelli
چکیده

Renal tumors are exceedingly rare in Multiple Endocrine Neoplasia type 1 (MEN1), a pleyotropic hereditary cancer disorder affecting the endocrine system. Herein we report a unique case of renal sarcomatoid carcinoma with concomitant ipsilateral non-secreting adrenal adenoma occurring in a young male MEN1 patient, previously operated for hyperparathyroidism and multiple pancreatic neuroendocrine neoplasms. Molecular analysis in the MEN1 locus at 11q13 showed loss of heterozygosity in the adrenal lesion, while kidney cancer was unrelated to MEN1 syndrome.

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عنوان ژورنال:
  • Endocrine journal

دوره 61 8  شماره 

صفحات  -

تاریخ انتشار 2014